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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Corneal avascularity is due to soluble VEGF receptor-1

Article Abstract:

A study shows that the cornea expresses soluble vascular endothelial growth factor (VEGF) receptor-1 (sVEGFR-1 or sflt-1) and that suppression of this endogenous VEGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice. The sflt-1 is necessary for preserving the avascular ambit of the cornea and it can be used in treating neovascular diseases.

Author: Curiel, David T., Qing Lin, Khurana, Tejvir S., Sakurai, Eiji, Ambati, Balamurali K., Ogura, Yuichiro, Ikeda, Sakae, Kleinman, Mark E., Green, Richard W., Albuquerque, Romulo J.C., Marsh, Helene, Nozaki, Miho, Singh, Nirbhai, Takeda, Astunobu, Jani, Pooja D., Suthar, Tushar, Richter, Elizabeth, Newcomb, Michael T., Caldwell, Ruth B., Orecchia, Angela, Samuelson, Don A., Agnew, Dalen W., Leger, Judy St., Mahasreshti, Parameshwar J., Kwan, Donna, Leiper, Lucy J., Collinson, J. Martin, Bogdanovich, Sasha
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Neovascularization, Vascular endothelial growth factor, RNA interference

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Local translation of RhoA regulates growth cone collapse

Article Abstract:

Neuronal development requires a highly coordinated regulation of the cytoskeleton with the developing axon. This regulation manifests in axonal branching, turning and pathfinding, presynaptic differentiation and growth come collapse and extension.

Author: Wu, Karen Y., Hengst, Ulrich, Cox, Llewellyn J., Macosko, Evan Z., Jeromin, Andreass, Urquhart, Erica R., Jaffery, Samie R.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Genetic aspects, Axons, Cytoskeleton, Genetic translation, Translation (Genetics)

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