Eomesodermin is required for mouse trophoblast development and mesoderm formation

Article Abstract:

The T-box gene Eomesodermin undertakes independent vital functions in extra-embryonic and embryonic tissues. It appears that Eomes may be required for the differentiation of trophectoderm and the formation of trophoblast stem cells. In the embryo proper, it is needed for mesoderm formation and the morphogenetic movements of gastrulation. Mouse embryos lacking Eomes arrest at the blastocyst stage. Mutant trophoectoderm does not differentiate into trophoblast, suggesting that Eomes could be necessary for the development of trophoblast stem cells.

Genetic aspects, Mice, Mice (Rodents), Stem cells, Mesoderm, Trophoblast, Trophoblasts

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Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

Article Abstract:

Transgenic mice afflicted with cystic fibrosis (CF) were used to test gene therapy protocols. The method involved using liposomes to transmit cystic fibrosis transmembrane conductance regulator (CFTR) gene to the lungs of the mice. Mutations in the CFTR gene is the cause of CF. Ion conductance defects in the trachea of the mice were cured after the CFTR treatment. This demonstrates the possibility of using gene therapy techniques in treating the pulmonary aspects of CF in humans.

Gene therapy, Cystic fibrosis

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Salmonella typhi uses CFTR to enter intestinal epithelial cells

Article Abstract:

Salmonella typhi, but not the linked murine pathogen Salmonella typhimurium, uses the cystic fibrosis transmembrane conductance regulator (CFTR) for entry into epithelial cells. It was established that S. typhi and S. typhimurium use different epithelial-cell receptors for translocation into the gastrointestinal submucosa. This could explain their different host ranges and disease symptoms. Resistance to typhoid fever could act as the selective factor for the heterozygote advantage conferred by the delta-F508 CFTR allele.

Epithelial cells, Salmonella typhimurium, Salmonella typhosa, Salmonella typhi

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