Cross-presentation by intercellular peptide transfer through gap junctions

Article Abstract:

Peptides are shown with a relative molecular mass of up to approximately 1,800 diffuse intercellularly through gap junctions unless a three-dimensional structure is imposed. A mechanism of antigen acquisition for cross-presentation is presented that couples the antigen presentation system of two adjacent cells and is lost in most tumors.

United States, T cells, Tumor antigens, Histocompatibility, Tumour antigens

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The major substrates for TAP in vivo are derived from newly synthesized proteins

Article Abstract:

The lateral mobility of the transporter TAP in living cells is investigated, showing that mobility increases when it is inactive and decreases when it translocates peptides.

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Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

Article Abstract:

The identification of kinase inhibitors clustered in one network around ATK1/PKB with antibiotic properties that prevent intracellular growth of bacteria is reported.

Bacterial growth, Actin, Phosphotransferases

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