Cryopyrin activates the inflammasome in response to toxins and ATP

Article Abstract:

Activation of mutations in cryopyrin are associated with familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal onset multisystem inflammatory disease, but it is seen that cryopyrin-deficient macrophages cannot activate capase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X receptor to decrease intracelluar K+ levels. It is concluded that cryopyrin is essential for inflammasome activation in response to signalling pathways triggered by ATP, nigericin and maitotoxin.

Toxins, Adenosine triphosphate, ATP, Agonists (Biochemistry)

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The ubiquitin ligase COP1 is a critical negative regulator of p53

Article Abstract:

The constitutively photomorphogenic 1 (COP1) expression in mammalian cells and tissues is examined with the help of real-time polymerase chain reaction (PCR) and in situ hybridization techniques. COP1 is a critical negative regulator of p53 representing a new pathway for the maintenance of p53 at low levels in unstressed cells.

Biological systems, Photomorphogenesis

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-KB signalling

Article Abstract:

Proteins from multiple species are analyzed to explore the mechanism by which A20 downregulates. Failure to downregulate NF-KB transcriptional activity results in chronic inflammation and cell death.

United States, Ubiquitin, Ligases, Ubiquitin-proteasome system

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