Common effector processing mediates cell-specific responses to stimuli

Article Abstract:

A systems-modelling approach is used for investigating how cell-specific signalling events are integrated through effector proteins to cause cell-specific outcomes. The results have shown that cell specificity has originated from the differential activation of kinases and other upstream transducers, thus enabling different cells to use common effectors to generate diverse outcomes.

United States, Cell cycle, Protein kinases, Structure, Transduction, Transduction (Genetics)

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Mechanotransduction through growth-factor shedding into the extracellular space

Article Abstract:

The morphological and biochemical responses of normal human bronchial epithelial (NHBE) cells to comprehensive stress are examined. The lateral intercellular space surrounding epithelial cells is shrunk by comprehensive stress, thereby triggering cellular signaling via autocrine binding of epidermal growth factor family ligands to the epidermal growth factor receptor.

Biological systems, Bronchial diseases

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Universal physical responses to stretch in the living cell

Article Abstract:

The studied have shown that in response to transient stretch the cytoskeleton has fluidized in such a way as to define a universal response class. The simple phenomenological laws are found to be both universal and primitive and hence comprise a striking intersection between the worlds of cell biology and soft matter physics.

Physiological aspects, Cytoskeleton, Cell research, Cytological research

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