Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

Article Abstract:

It has been established that immature erythroid cells express a number of death receptors whose ligands are produced by mature erythroblasts. Interaction between death receptors and their ligands leads to caspase-mediated degradation of the transcription factor GATA-1 and blockade of erythropoiesis. It is suggested that caspases cause the arrest of erythroid differentiation through cleavage of GATA-1.

Cell death, Pure red cell aplasia

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Differential modulation of endotoxin responsiveness by uman caspase-12 polymorphisms

Article Abstract:

The single nucleotide polymorphism encoding caspase proenzyme (Csp 12-L) in populations of African descent is examined. Caspase 12-L is responsible for attenuating the inflammatory and innate immune response to endotoxins and the frequency of Csp 12-L allele increases in African American individuals with severe sepsis.

Africa, Genetic polymorphisms, Chemical properties, Casanthranol

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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

Article Abstract:

A novel role for a caspase is described in dampening responses to d. It is shown that in mice, gene-targeted deletion of caspase-12 renders animals resistant to peritonitis and septic shock.

United States, Causes of, Physiological aspects, Mice, Bacterial infections, House mouse, Sepsis

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