NMDA-receptor mediated, cell-specific integration of neurons in adult dentate gyrus

Article Abstract:

A retrovirus-mediated, single-cell gene knockout technique in mice was developed to study survival of new neurons in adult dentate gyrus. It was seen that the survival of new neurons is competitively regulated by their own NMDA-type glutamate receptor during a short period soon after neuronal birth indicating that the survival of new neurons and the resulting formation of new circuits are regulated in an input-dependent cell-specific manner.

Norway, Analysis, Observations, Growth, Fluorescence microscopy, Electron microscopy, Methyl aspartate, N-methyl-D-aspartate, Company growth, Structure

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Routing of spike series by dynamic circuits in the hippocampus

Article Abstract:

Simultaneous somatic and dendritic recordings in rat hippocampal slices are used to show that during a series of action potentials in pyramidal cells recurrent inhibition rapidly shifts from their soma to the apical dendrites. The onset of a series of action potentials and the rate of action potentials in the series are selectively captured and transformed into different spatial patterns of recurrent inhibition.

Central nervous system

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Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

Article Abstract:

It is shown that young granule cells in the adult hippocampus differ substantially from mature granule cells in both active and passive membrane properties. Newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories.

Neuroplasticity

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