Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor
Article Abstract:
A class-2 cytokine receptor-ligand complex is made visible by the study of the crystal structure of interferon-gamma bound to the extracellular portion of its high-affinity cell-surface receptor. Two receptor molecules are bound by the interferon-gamma homodimer in the complex. The receptors are separated by 27 angstroms and there is no interaction between them. A conformational change including the formation of a 3(sub 10) helix in the flexible AB loop of interferon is observed upon receptor binding.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
Article Abstract:
Chemoattractant cytokine molecules, or chemokines, control lymphocyte traffic, partly by triggering arrest of lymphocytes rolling on endothelium. Many systemic memory T cells in blood are found to carry the chemokine receptor CCR4, responding to its ligands TARC and MDC. It is suggested that CCR4 and TARC are important in recognition of skin vasculature by circulating T cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Control of the electronic phase off a manganite by mode-selective vibrational excitation
Article Abstract:
A report on the ultrafast switching of the electonic phase of a magnetoresistive manganite through direct excitation of a photon mode at 71 meV is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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