Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
Article Abstract:
SR proteins act as inhibitors or activators of splicing depending on the precursor messenger (pre-mRNA) sites to which they bind. SR proteins bind to an intronic repressor protein and suppress IIIa pre-mRNA splicing. The suppressive effect vanishes on removal of the repressor protein. SR proteins are responsible for the control of adenovirus L1 alternative splicing during virus infection. The steady-state levels of SR proteins, however, remain constant from early to late infection indicating that the proteins are inactivated during the later stages.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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The RNA splicing factor hSlu7 is required for correct 3' splice-site choice
Article Abstract:
It has been established that normal adenine-guanine (AG) selection takes place in two clear stages. In the first, the correct AG is identified but sequestered, with the metazoan splicing factor hSlu7 not being needed. In the second, the sequestered AG is exposed, with exon 1 being directed to this AG. This stage needs hSlu7. It is concluded that hSlu7 is required to hold exon 1 tightly within the spliceosome for attack on a prespecified AG.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A two-step mechanism for 5' and 3' splice-site pairing
Article Abstract:
In metazoan pecursor messenger RNAs (pre-mRNAs), the 5' and 3' splice-site pairing with long introns occurs in two different steps. If the specific downstream sequence elements are present in the 3' trans-splicing substrate, the 5' and 3' splice sites positioned on different synthetic pre-mRNAs undergo trans-splicing. The selection of the trans 5' splice can develop after the association of the A complex on the trans 3' substrate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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