Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

Article Abstract:

The ligand-binding interactions of human retinoic acid receptor (RAR)-gamma bound to all-trans retinoic acid can be determined through the crystal structure of the ligand-binding domain (LBD) which also indicates the involvement of an electrostatic mechanism in the binding. Retinoic acid X receptor-alpha apo-LBD has a similar overall fold but the carboxy-terminal is different in RAR-gamma as it folds back toward the LBD core. The binding of retinoid to the LBD of the human RAR-gamma appears to involve a mouse trap mechanism, whose conformational changes allow for the binding of transcriptional mediators, and dynamic interactions.

Observations, Morphology (Biology), Ligand binding (Biochemistry), Morphology

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Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

Article Abstract:

Results indicate that a co-regulatory-like function of activated dioxin receptor/Arnt transcription factor modulate the nuclear receptor family members ER-mediated oestrogen signalling resulting in adverse oestrogen-related actions of dioxin-type environmental contaminants.

Japan, France, Pesticide and Other Agricultural Chemical Manufacturing, Agricultural chemicals, not elsewhere classified, Dioxin, Physiological aspects, Cellular signal transduction, Cell receptors, Dioxins, Enzyme regulation

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Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

Article Abstract:

Research is presented concerning the development of a technique for the creation of spatio-temporally controled somatic mutations in mice. The role of RXRalpha in hair cycling is discussed.

Letter to the Editor, Epidermis, Hair follicles

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