Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA

Article Abstract:

The study of the X-ray crystal structure of the heterodimer of bZIP regions in the DNA with c-Fos and c-Jun binding reveals that the two subunits are made up of continuous alpha-helices. Complexes which can bind to 5'-TGAGTCA-3' DNA elements are formed by the heterodimerization of the Fos and Jun families of the eukaryotic transcription factors. An asymmetric coil is formed by the carboxy-terminal regions of the heterodimers and the specific contacts with the DNA are made by the amino terminal regions.

Genetic transcription, Transcription (Genetics), Oncogenes

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Structure of an auxlin-bound clathrin coat and its implications for the mechanism of uncoating

Article Abstract:

The study uses electron cryomicroscopy to determine 12-A-resolution structures of in-vitro-assembled clathrin coats in association with a carboxy-terminal fragment of auxlin that contains both the clathrin-binding region and the J-domain. Auxlin binds within the clathrin lattice near contacts between an inward-projecting C-terminal helical tripod and the crossing of two 'ankle' segments.

United States, Science & research, Drugs, Cellular Protein, In-Vitro Diagnostic Substance Manufacturing, Cellular proteins, Clathrin

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Structure of the reovirus core at 3.7 A resolution

Article Abstract:

Analysis of the structure of the reovirus core by X-ray crystallography reveals alternative and nonequivalent contacts made by several surfaces of two of its proteins.

Reoviruses

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