Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel

Article Abstract:

The cyclic adenosine 5'-diphosphoribose (cADPR) found in many mammalian tissues stimulates the cardiac but the skeletal isoform of the ryanodine receptor Ca2+ channel (RyRc) is not activated by it. An endogenous activation of the non-skeletal type of RyRc is cADPR, and in Ca2+ signalling, its role may be similar to inositol 1, 4, 5-triphosphate.

Analysis, Muscles, Sarcoplasmic reticulum

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Solace for the broken-hearted?

Article Abstract:

The heart was thought to lack the capacity to regenerate after injury. But the identification of progenitor cells in the heart that can divide and mature into heart muscle suggests that the heart has some regenerative capacity after all.

United States, Science & research, Heart

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Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells

Article Abstract:

L-type Ca2+ channels (LCCs) and the coupling with ryanodine receptors are discussed.

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