Cyclin-dependent kinases regulate the antiproliferative function of Smads
Article Abstract:
Smad3, which has a key function in mediating TGF-Beta growth-inhibitory response, is also a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2 and inhibits cell-cycle progression from G1 to S phase. Findings indicate that CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function as well as its contribution to tumorigenesis and TGF-Beta resistance in cancers.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs
Article Abstract:
A study conducted shows that the p90rsk, the kinase immediately downstream from Mos-MAPK, directly targets Erp1 for cytostatic factor (CSF) arrest in Xenopus oocytes. This study results clarify the direct link of the classical Mos-MAPK pathway to Erp1 in meiotic arrest of vertebrate oocytes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Article Abstract:
A cAMP-responsive signaling complex maintained by the muscle-specific A-kinase anchoring protein (mAKAP) that includes PKA, PDE4D3 and Epac1 is identified. Pharmacological and molecular manipulations of the mAKAP complex show that anchored ERK5 can induce cardiomyocyte hypertrophy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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