DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Article Abstract:
The function of a candidate DNA sensor, which was earlier called as DLM-1 or Z-DNA binding protein 1 (ZBP1), is reported and an alternative name of DAI (DNA-dependent activator of IFN-regulatory factors) is proposed. The analysis has underscored an integral role of DAI (DLM-1/ZBP1) in the DNA-mediated activation of innate immune responses and has helped in understanding the signaling mechanisms underlying DNA-associated antimicrobial immunity and autoimmune disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
Article Abstract:
The spatiotemporal regulation of MyD88-IRF-7 singnalling that is critical for a high-level robust type I interferon (IFN) induction in response to Toll-like receptor 9 (TLR9) activation is demonstrated. An insight into the regulation of TLR9 signalling in space, potentially suggesting a new avenue for therapeutic intervention is offered.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Intergation of interferon alpha/beta signalling to p53 responses in tumor suppression and antiviral defence
Article Abstract:
The authors have investigated tumour suppressor p53 and interferon-alpha and -beta. The results demonstrate that p53 gene induction by interferon-alpha and -beta is important for tumour suppression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: History and management of crown-fire ecosystems: a summary and response. Historic fire regime in Southern California shrublands
- Abstracts: Identification and characterization of the vesicular GABA transporter. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
- Abstracts: Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Drosophila hygrosensation requires the TRP channels water witch and nanchung
- Abstracts: A systematic test of an enterprise strategy for community-based biodiversity conservation. Benzoin gardens in North Sumatra, Indonesia: effects of management on tree diversity
- Abstracts: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Motor proteins branch out