Decapentaplegic restricts the domain of wingless during Drosophila limb patterning

Article Abstract:

The Drosophila decapentaplegic protein (Dpp) blocks the activation, by the Shh-hedgehog protein in the dorsal regions, of wingless (wg) gene and limits wg expression to the distal regions of developing limbs. Dorsal cells of the distal leg segments lacking Dpp receptors produce abnormalities while mutant ventral cells have no effect on development. The wings of adults containing the mutant cells are small and contain blisters, and ectopic veins and wing margins. The negative regulation by Dpp is important for restricting signaling factors to certain cells and determining limb patterning.

Analysis, Abnormalities, Physiological aspects, Proteins, Developmental biology, Gene expression, Extremities (Anatomy)

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Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants

Article Abstract:

Apoptosis is a form of cell death essential for normal development and health. However high apoptosis levels are linked to several degenerative diseases. The therapeutic utility of blocking cell death is still unclear. The mechanism of cell death in Drosophila mutant strains showing age-related retinal degeneration was investigated, and retinal cell death in rdgC and ninaERH27/+ flies was due to apoptosis, and was blocked by expression of the protein p35.

Observations, Cell death

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