Defective platelet activation in Galpha(sub q)-deficient mice

Article Abstract:

Research shows that physiological platelet activators have no stimulatory affect on blood platelets from mice deficient in the alpha-subunit of the heterotrimeric guanine-nucleotide-binding protein. Extended bleeding times are noted. Thus, platelet activators need Galpha(sub q) to function properly. Galpha(sub i) or Beta gamma subunits of the heterotrimeric G proteins are not adequate substitutes for platelet activators. Evidence suggests that future drug development programs may use Galpha(sub q) to block platelet activation.

Blood platelets, Platelet activation

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Structure of a replication-terminator protein complexed with DNA

Article Abstract:

A model of the structure of the replicator-terminator protein (Tus) bound to terminus-site (Ter) was developed using X-ray crystallization at a resolution of 2.7 angstrom. It was revealed that the Tus folds into an architecture divided by two domains by a central basic cleft which links to a locally deformed Ter DNA. The cleft makes extensive contact with the major groove through two interdomain beta-strands. Such a configuration may explain the replicator-fork systems' unique ability to halt a fork in only one direction.

Models, Genetic aspects, Escherichia coli, Chromosome replication

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A signal terminator

Article Abstract:

Pretreatment with the recombinant enzyme, human plasma platelet-activating factor (PAF) acetylhydrolase, effectively blocks more than 80% of the responses in PAF-induced paw oedema and micro-vascular leakage in pleurisy in rats. PAF is a very potent factor causing cell damage by several mechanisms during inflammation. PAF participates both in normal cell function as well as in pathology. These molecules are naturally synthesized in response to normal physiological stimuli but can be harmful in high concentrations.

Inflammation, Inflammation mediators

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