Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR

Article Abstract:

The expression of recombinant cystic fibrosis (CF) genes by means of adeno-associated virus vectors in CF bronchial epithelial cells stops the defective Cl- secretion, produces conductance Cl- channels and revives protein kinase A stimulation of outwardly rectifying Cl- channels. Hence it may be possible to use gene expression to treat CF, a severe genetic disease that results from a defective gene for the cystic fibrosis transmembrane conductance regulator protein.

Health aspects, Genetic aspects, Genetic recombination, Protein kinases, Cystic fibrosis, Chloride channels

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Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

Article Abstract:

C-Src initiates angiogenesis which induces tumor development while vascular endothelial growth factor (VEGF) is a downstream target for c-Src. Hypoxia activates a tyrosine kinase which helps in signalling triggered by growth factors and ultraviolet light. VEGF induction is prevented by genistein which is an inhibitor of protein tyrosine kinase. Inhibitors of protein tyrosine kinases, targeting c-Src, may be applied in antiangiogenic therapy.

Hypoxia, Anoxia, Growth factors, Vascular endothelium

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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

Article Abstract:

Polycystin-1 and 2 co-assembly is found to produce unique cation-permeable currents and regulate renal tubular morphology and function.

Polycystic kidney disease

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