Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor
Article Abstract:
The role of beta/A4 amyloid protein precursor (APP) in the pathology of Alzheimer's disease was made clearer when APP was found to cause neuronal degeneration in mice. APP is a large membrane-bound glycoprotein that consists partly of amyloid fibrils. Deposits of these fibrils in the brain characterizes the pathophysiology of Alzheimer's. The finding that genetically overexpressed APP can affect post-mitotic neurons should stimulate further research linking APP with Alzheimer's disease and similar neuropathological disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Neurotoxicity of beta-amyloid
Article Abstract:
The role of beta-amyloid plaques in the pathogenesis of Alzheimer's disease remains in dispute. Beta-amyloid precursor protein (APP) produces the abnormal deposits of beta-amyloid that are known to form in the brains of Alzheimer's patients. However, the conclusion that APP neurotoxicity starts the development of Alzheimer's disease could be strengthened by answering questions such as APP's effect on cultured neurons. However, another view is that amyloid deposits outside the neurons cause the neuronal degeneration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
New mice for old questions
Article Abstract:
Scientists Kuro-o's genetic research identifying the mutant klotho (kl) gene and its possible role in human pathology is interesting but not necessary likely. Kuro-o has managed to give a non-mutant phenotype to mice with a genetically-mutated kl genotype and suggests that kl is potent in the aging human genotype. However, a number of questions regarding beta-glucosidase gene domains must be answered before such a conclusion can be drawn.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Molecular cloning and overexpression of the human FK506-binding protein FKBP. Regulatory intramolecular association in a tyrosine kinase of the Tec family
- Abstracts: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein
- Abstracts: Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
- Abstracts: Characterization of low-dimensional dynamics in the crayfish caudal photoreceptor. Patterns of elevated free calcium and calmodulin activation in living cells
- Abstracts: Spontaneous assembly of a hinged coordination network. Biasing reaction pathways with mechanical force. Carborod molecular scaffolding