Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila
Article Abstract:
The extension of the planar filopodia, a common attribute of wing imaginal disc cells promoted by Delta is described. Their experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing that these membrane specializations mediate long-range lateral inhibition.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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A self-organising system of repressor gradients establishes segmental complexity in Drosophila
Article Abstract:
The study shows that opposing gradients of two Drosophila transcriptional repressors, Hunchback (Hb) and Knirps (Kni), position several segments by differentially repressing two distinct regulatory regions. The results indicate that complex developmental expression patterns can be generated by simple repressor gradient.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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The immune response of Drosophila
Article Abstract:
Research reveals that most of the Drosophila host defence genes are homologous or similar to mammalian immune defence genes. Drosophila responds to challenges by microorganisms by immunologically producing effector molecules. Data indicate that antimicrobial peptides are predominant molecules of the defence mechanism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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