Developmental selection of var gene expression in Plasmodium falciparum

Article Abstract:

The transcription and expression of var genes in FCR3S1.2, a cloned and phenotypically homogenous parasite culture, has been studied. The var gene messenger RNAs were amplified from unsynchronized cultures. Products of amplification were cloned by RT-PCR, then sequenced. It was found that only 30% of the sequences corresponded to the FCR3S1.2 var-1 PfEMP-1. A single P. falciparum parasite transcribes multiple var genes simultaneously, but selects just one PfEMP-1 to reach the host cell surface.

Observations, Genetic transcription, Transcription (Genetics), Plasmodium falciparum

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What do yeast proteins do?

Article Abstract:

Ross-MacDonald and colleagues have described a new genome-wide process for the large-scale analysis of gene function in the Saccharomyces cerevisiae yeast. This provides information for around one-third of all genes in the yeast genome, giving access to mutant strains and cloned reagents, for analysis by the scientific community.

Research, Genomes, Saccharomyces cerevisiae

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