Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by G BetaY
Article Abstract:
Inward rectifier potassium channels are responsible for modulating electrical activity in a number of cell types, and they are in turn regulated by protein kinases, or G proteins. An experiment has found that a number of cloned inward rectifier potassium channels bind with PIP2 in a direct manner, and channel activity is correlated with this binding. The cloned channels are activated by spplying the PIP2 or ATP liposomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Clathrin's Achilles ankle
Article Abstract:
Cells transport tiny, membrane-bound spheres called vesicles, which bud off from the membrane, fuse with a target membrane, and sort by so-called coat protein, of which one of the best known is clathrin. Clathrin-coated vesicles serve numerous functions in the cell and internalize nutrient receptors and signaling receptors, regulating a cell's sustenance and its stimulation by environmental factors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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