A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

Article Abstract:

The type III effector HopU1 is shown to be a mono-ADP-ribosyltransferase (ADP-RT), where HopU1 suppresses plant innate immunity in a manner dependent on its ADP-RT active site. The results provide a pathogenic strategy where the ADP-ribosylation of RNA-binding proteins quells host immunity by affecting RNA metabolism and the plant defence transcriptome.

Plant-pathogen relationships, RNA, Adenosine diphosphate, Chemical properties, Binding proteins, Plant immunology, Disease resistance (Plants), Report

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Pink, parkin and the brain

Article Abstract:

Parkinson's disease result from environmental exposures superimposed on an individual's genetic susceptibilities and a small fraction by single cell mutations. The discoveries of causative mutations in the DJ-1 and PINK1 gene have confirmed the mitochondrial hypothesis of Parkinson's disease.

Pennsylvania, Health aspects, Occupational health and safety, Causes of, Genetic aspects, Parkinson's disease, Parkinson disease, Ubiquitin-proteasome system, Occupational exposure

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