Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Article Abstract:

Removal of Drosophila PTEN-induced putative kinase 1 (PINK1) homologue function results in male sterility, apoptotic muscle degeneration, defects in mitochondrial morphology and increased sensitivity to multiple stresses including oxidative stress. The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis.

Causes of, Risk factors, Mitochondrial diseases, Oxidative stress

---

Mitochondrial dysfunction in Drosophila PINK1 mutants in complemented by parkin

Article Abstract:

The Drosophilia PTEN-induced putative kinase 1 (PINK1) mutants exhibit indirect flight muscle and dopaminergic neuronal degeneration accompanied by locomotive defects. Transmission electron microscopy analysis and a rescue experiment with Drosophila Bcl-2 demonstrated that mitrocondrial dysfunction accounts for the degenerative changes in all phenotypes of PINK1 mutants.

Diagnosis, Genetic aspects, Mitochondria

---

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Article Abstract:

The article attempts to explain the biochemical features of AMP-activated protein kinase in cells using the Drosophila model system.

United States, Cells (Biology), Cells, Protein kinases, Cyclic adenylic acid, Properties, Cyclic AMP-dependent protein kinases

Similar abstracts:

• Abstracts: Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. A membrane protein requires for dislocation of misfolded proteins from the ER
• Abstracts: Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs. Cell cycle unleashed
• Abstracts: Time lag between deforestation and bird extinction in tropical forest fragments. One Hundred Fifty Years of Change in Forest Bird Breeding Habitat: Estimates of Species Distributions
• Abstracts: A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans. Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae
• Abstracts: Caching decisions by grey squirrels: a test of the handling time and perishability hypotheses. The innate basis of food-hoarding decisions in grey squirrels: evidence for behavioural adaptations to the oaks

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.