Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

Article Abstract:

The interacting partners of wild-type US2 are compared with those of a dislocation-incompetent US2 mutant and the signal peptide peptidase (SPP) is identified as a partner for the active form of US2. A decrease in SPP levels by RNA-mediated interference inhibits heavy-chain dislocation by US2 and not by US11.

Usage, Prevention, Cytomegalovirus infections, Signal peptides, Properties, Western immunoblotting, Western blot, RNA interference

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A lipid-based model for the creating of an escape hatch from the endoplasmic reticulum

Article Abstract:

A model is described for the involvement of lipid rearrangements in the execution of crucial steps in glycoprotein quality control. This lipid-based model has helped in creating an escape route from the endoplasmic reticulum (ER).

Health aspects, Glycoproteins, Proteolysis, Lipid membranes, Structure

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A membrane protein requires for dislocation of misfolded proteins from the ER

Article Abstract:

The protein Derlin-1 is essential for the degradation and dislocation of misfolded proteins from the endoplasmic reticulum. The protein is identified through an affinity approach.

Membrane proteins, Protein research

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