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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

E-cadgerin germline mutations in familial gastric cancer

Article Abstract:

Research into familial clustering of cases of gastric cancer has used genetic linkage analysis to show significant linkage to markers flanking the gene for the calcium-dependent cell-adhesion protein E-cadherin. Reduced E-cadherin expression is connected with aggressive, poorly differentiated carcinomas. Loss of E-cadherin function and the related disruption of normal cell-cell adhesion could also play a part in the initiation of cell proliferation by permitting escape from growth-control signals.

Author: Reeve, Anthony E., Miller, Andrew, Guilford, Parry, Hopkins, Justin, Harraway, James, McLeod, Maybelle, McLeod, Ngahiraka, Harawira, Pauline, Taite, Huriana, Scoular, Robin
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Causes of, Cell adhesion, Stomach cancer

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Defective myosin VIIA gene responsible for Usher syndrome type 1B

Article Abstract:

Genetic studies on the Usher syndrome type I (USH-1), which causes the dual sensory defect deaf-blindness in humans, through an analysis of mutations containing the shaker-1 mutation, indicate myosin VIIA encoded gene to be the cause of USH1B. A primary cytoskeletal protein deficiency due to the mutations in the protein's motor domain N-terminal causes USH1B, which induces cytoskeletal defects in the affected.

Author: Walsh, James, Steel, Karen P., Munnich, Arnold, Petit, Christine, Kimberling, William J., Weil, Dominique, Blanchard, Stephane, Kaplan, Josseline, Guilford, Parry, Gibson, Fernando, Mburu, Philomena, Varela, Anabel, Levilliers, Jacqueline, Weston, Michael D., Kelley, Phillip M., Wagenaar, Mariette, Levi-Acobas, Fabienne, Larget-Piet, Dominique, Brown, Steve D.M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Analysis, Mutation (Biology), Mutation, Cytoskeletal proteins, Blind deaf persons, Blind-deaf, Usher's syndrome

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Connexin 26 gene linked to a dominant deafness

Article Abstract:

Genetic research shows that deafness is caused by the expression of a gene Cx26 mutation. The mutated gene caused deafness in both dominant and recessive gene expression. Evidence suggests that Cx26 causes a minor proportion of autosomal dominant deafness, but is responsible for a large proportion of hearing loss cases in its autosomal recessive form.

Author: Petit, Christine, Weil, Dominique, Levi-Acobas, Fabienne, Denoyelle, Francoise, Lina-Granade, Genevieve, Plauchu, Henri, Bruzzone, Roberto, Chaib, Hassan
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Genetic aspects, Human genetics, Hearing

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