Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

Article Abstract:

Research is presented concerning the influence of phosphoinositide-3-OH kinases in the regulation of a number of cell functions including the suppression of tumors and tumorigeneisis.

Colorectal cancer, Lipid metabolism, Transforming growth factors, Letter to the Editor

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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-Gamma and PTEN

Article Abstract:

Electric fields, of strength equal to those detected endogenously, are shown to be the prime directional cue for direct cell migration during wound healing in multicellular organisms. Electric stimulation activates signaling pathways for activation of Src and inositol-phospholipid signaling, which polarized in the direction of cell migration.

United States, Science & research, Health aspects, Tumor suppressor genes, Cell migration, Wound healing, Electric fields, Tumour suppressor genes

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Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

Article Abstract:

An examination of the role of Sek1, a direct activator of stress-activated protein kinases or Jun N-terminal kinases, in development and apoptosis revealed that the induction of apoptosis in reaction to environmental stresses in embryonic stem and T cells was not affected by sek1 mutation. Instead, sek1 was found to protect thymocytes from apoptosis mediated by CD95 (fas)- and CD3. Results also suggest that SEK1 mediates survival signals in T-cell development.

Cell death, Protein kinases

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