Elongation factor-1-alpha gene determines susceptibility to transformation

Article Abstract:

Elongation factor-1-alpha (EF-1-alpha), a GTP-binding protein required for eukaryotic translational apparatus, has been identified as A31-I-13, a BALB/c 3T3 mouse fibroblast variant whose constitutive expression renders the fibroblasts vulnerable to malignant transformation initiated by 3-methylcholanthrene and ultraviolet light. EF-1-alpha messenger RNA is genetically expressed by variant A31-I-13, indicating that the removal of translational components makes cells more likely to become cancerous.

Genetic aspects, G proteins, Carcinogenesis, Cell transformation

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Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation

Article Abstract:

Ultraviolet irradiation of cells arrest them in the G1 phase of the cell cycle which is accompanied by an increase in tyrosine phosphorylation of a cyclin-dependent kinase, Cdk4. Cells in G1, S and G2 cell cycle phases are arrested on exposure to ultraviolet light. The dephosphorylation of Cdk4 in the G1 phase is required for the S phase and cells expressing Cdk4 that is unphosphorylated do not arrest cells in the G1 phase leading to chromosomal abnormalities and ultimately cell death.

Influence, Observations, Ultraviolet radiation, Cell cycle, Protein kinases

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A kinase from fission yeast responsible for blocking mitosis in S phase

Article Abstract:

The cds1+ (checking DNA synthesis) gene isolated from the fission virus forms a protein kinase which does not allow the cell to divide till DNA synthesis is over. The kinase interacts with the DNA polymerase alpha to control the cell division. In cells lacking this control, frequently division occurring before the completion of DNA synthesis and cell without nuclei are formed.

Yeast, Yeast (Food product), Mitosis

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