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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Localization of the malignant hyperthermia susceptibility locus to chromosome 19q12-13.2

Article Abstract:

Malignant hyperthermia (MH) is one of the main causes of death due to anesthesia. The accelerated muscle metabolism creates heat faster than the body can dissipate it. Susceptibility to MH is inherited as an autosomal dominant genetic trait. Fortunately for individuals from families with a history of MH, susceptibility can be predicted on the basis of a muscle biopsy. This same muscle biopsy can be used as a genetic test to examine the segregation of the gene as it is passed from generation to generation. Previous research has established the order of 14 genetic markers along human chromosome 19. When these markers are followed in the pedigree, along with MH susceptibility, it is possible to narrow the possible location of the MH gene to the q12-13.2 region of chromosome 19. Related studies have indicated that this region is near the location of the gene for the ryanodine receptor, which controls calcium release in muscle tissue. This function may be the precise locus of the defect which causes malignant hyperthermia. (Consumer Summary produced by Reliance Medical Information, Inc.)

Author: Healy, J.M. Sandra, McCarthy, Tommie V., Heffron, James J.A., Lehane, Mary, Deufel, Thomas, Lehmann-Horn, Frank, Farrall, Martin, Johnson, Kieth
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1990
Linkage (Genetics), Malignant hyperthermia

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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Article Abstract:

The effects of single nucleotide polymorphisms (SNPs) on the presence of childhood onset asthma are analyzed by genomic-wide association. The results have shown that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.

Author: Farrall, Martin, Lathrop, G. Mark, Strachan, David, Depner, Martin, Abecasis, Goncalo R., von Mutius, Erika, Moffatt, Miriam F., Kabesch, Michael, Liming Liang, Dixon, Anna L., Heath, Simon, von Berg, Andrea, Bufe, Albrecht, Rietschel, Ernst, Heinzmann, Andrea, Simma, Burkard, Frischer, Thomas, Willis-Owen, Saffron A.G., Wong, Kenny C.C., Illig, Thomas, Vogelberg, Christian, Weiland, Stephan K., Gut, Ivo G., Cookson, William O.C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
United Kingdom, Science & research, Analysis, Causes of, Asthma in children, Childhood asthma, Gene expression, Single nucleotide polymorphisms

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Cyclin D control of growth rate in plants

Article Abstract:

Overall plant growth rate is directly connected with cell division. It is suggested that environmental and developmental controls of growth rate function by controlling CycD kinase activity and cell division.

Author: Cockcroft, Claire E., Boer, Bart G.W. den, Healy, J.M. Sandra, Murray, James A.H.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Growth (Plants), Plant growth

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Subjects list: Research, Genetic aspects
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