Encapsulation of bilayer vesicles by self-assembly

Article Abstract:

It is possible to produce a multicompartmental aggregate of tethered vesicles encapsulated within a larger bilayer vesicle by using molecular-recognition processes mediated by lipophilic receptors and substrates. Researchers have named these encapsulated aggregates vesosomes. A combination of cochleate cylinders and ligand-receptor interactions can alone produce a spontaneous encapsulation of the vesicle aggregate. This takes place gently, thus ensuring that the integrity of the interior membranes is maintained.

Research, Microencapsulation

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Doxorubicin in sterically stabilized liposomes

Article Abstract:

Doxorubicin is the first FDA-approved liposomal therapeutic drug in the US and is being used in the treatment of Kaposi sarcoma. The drug is encapsulated due to its precipitation with sulphate in the liposome interior. More than 2,000 patients with Kaposi sarcoma have been treated with doxorubicin, which shows reduced toxicity and a high response rate. Enhanced liposome activity and drug retention substantially increases the anticancer activity of doxorubicin. The drug delivery system of liposomes is discussed.

Evaluation, Physiological aspects, Chemotherapy, Kaposi's sarcoma, Liposomes, Doxorubicin

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