Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor

Article Abstract:

The effect of ryanodine receptor (RyR-1) in dihydropyridine channel activity is determined using dyspedic mice myotubes as a destroyed RyR-1 gene. There was no excitation-contraction coupling recorded in dyspedic myotubes. L-type Ca2+-current density was reduced 30 times than the original. The application of of RyR-1 complementary DNA to dyspedic myotubes caused normal excitation-contraction coupling activity and normalized L-type Ca2+ currents. The enhanced L-type current was a result of the skeletal isoform of the dihydropyridine receptor (DHPR) as a calcium channel enhanced by a retrograde signal of RyR-1.

Physiological aspects, Cell membranes, Plasma membranes, Excitation (Physiology)

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Function of a truncated dihydropyridine receptor as both voltage sensor and calcium channel

Article Abstract:

The dihydropyridine (DHP) receptor in skeletal muscle serves both as a calcium channel and as a voltage sensor for excitation-contraction coupling. These two functions have been proposed to correspond to the two different forms of DHP receptors, the long and the short. But the short form performs both functions, as revealed by the construction of a protein corresponding to the truncated DHP receptor, using a complimentary DNA. It has not been determined whether these two functions are performed simultaneously by individual DHP receptors.

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Csk controls antigen receptor-mediated development and selection of T-lineage cells

Article Abstract:

Pre-T and alpha beta T cell receptors send signals upon which the development and function of alpha beta lymphocytes depend. The protein tyrosine kinases (PTKs) of the Src family, Lck and Fyn, are activated when these receptors are engaged, although it is unclear how the differentiation steps triggered by preTCR and alpha betaTCR are directed by the activation of Src family of PTKs. It is shown that preTCR/alpha beta TCR-mediated control of the development of alpha beta T cells require carboxy-terminal Src kinase and its substrates.

Cell differentiation, Morphogenesis, T cells, Embryology, Animal embryology

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