Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
Article Abstract:
Hedgehog (Hh) proteins are involved in short and long-range signalling to pattern tissue during invertebrate and vertebrate development. A new Drosophila gene, tout-velu, has been identified. It is shown to be require for diffusion of Hh, and encodes an integral membrane protein belonging to the EXT gene family, which are involved in the human multiple exostoses syndrome. Results suggest that the multiple exostoses syndrome is linked to abnormal diffusion of Hh proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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A drosophila NSF mutant
Article Abstract:
The N-ethylmaleimide-sensitive fusion protein (NSF) is found to be encoded by the comt gene in Drosophila melanogaster based on electrophysiological analysis of flies with mutations in the comt locus. The analysis also provided evidence for a synaptic transmission function for NSF based on the behavior of flight muscles in mutant and non-mutant flies when subjected to nonpermissive temperatures.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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