Exocytosis goes with a SNAP

Article Abstract:

Researchers have shown that key components of the regulated fusion of the synaptic vessels are involved in both regulated and constitutive exocytosis. They showed that synaptosomal-associated protein (SNAP-25) participates in the formation of a complex which includes synaptobrevin II. The complex is essential for synaptic vessel exocytosis. They also showed that SNAP-25 is homologous to part of the yeast SEC9 gene product. These findings support the idea that SNAP-25 is central to both regulated and constitutive exocytosis.

Models, Messenger RNA, Exocytosis

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A presynaptic inositol-5-phosphatase

Article Abstract:

Synaptojanin is a nerve terminal protein that belongs to the inositol-5-phosphatase family. It has 5-phosphatase activity and an amino-terminal domain that matches the yeast protein Sac1 (Rsd1). Aside from dynamin, synaptojanin is the only other major brain protein that binds the SH3 domain of the presynaptic protein amphiphysin. The results of an analysis indicate a relationship between phosphoinositide metabolism and synaptic vesicle recycling.

Inositol phosphates

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Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

Article Abstract:

During endocytosis, one of the factors that helps clathrin and the clathrin adaptor protein AP-2 to produce an invaginated bud at the cell membrane is a clathrin-coat-associated protein called Eps15. A new study investigates the action of Eps15 using the protein epsin which is found in presynaptic nerve terminals. It is shown that disruption of the epsin function blocks clathrin-mediated endoyctosis.

Genetic aspects, Observations, Protein research, Endocytosis, Clathrin

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