Exogenous control of mammalian gene expression through modulation of RNA self -cleavage
Article Abstract:
Recent studies on the control of specific metabolic pathways in bacteria have documented the existence of entirely RNA-based mechanisms for controlling gene expression. It is shown that an analogous RNA-based gene regulation system can effectively be designed for mammalian cells via the incorporation of sequences encoding self-cleaving RNA motifs into the transcriptional unit of a gene or vector. In conjunction with other emerging technologies, this methodology may be particularly applicable to the development of gene regulation systems.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Birth of parthenogenetic mice that can develop to adulthood
Article Abstract:
The development of a viable parthenogenetic mouse individual from a reconstructed oocyte containing two haploid sets of maternal genome, derived from non-growing and fully-grown oocytes is explained. This development was made possible by the appropriate expression of the Igf2 and H19 genes with other imprinted genes, using mutant mice with a 13-kilobase deletion in the H19 gene as non-growing oocytes donors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
A FADD-dependent innate immune mechanism in mammalian cells
Article Abstract:
A report is conducted on the mammalian cells lacking the death-domain-containing protein FADD, which are defective in intracellular dsRNA-activated gene expression. The data obtained suggest the existence of a conserved pathogen recognition pathway in mammalian cells that is essential for the optimal induction of type I interferons and other genes important for host defence.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Proto-vav and gene expression. Correlations in intronless DNA
- Abstracts: Genonomics: Gene expression meets genetics. Control of gene expression by a natural metabolite-responsive ribozyme
- Abstracts: Coherent quantum control of two-photon transitions by a femtosecond laser pulse. Discretizing light behaviour in linear and nonlinear waveguide lattices
- Abstracts: Identification of a mammalian mitochondrial porphyrin transporter. Synthesis of a Mobius aromatic hydrocarbon
- Abstracts: Dynamic control of positional information in the early Drosophila embryo