Fast vesicle replenishment allows indefatigable signaling at the first auditory synapse

Article Abstract:

An attempt is made to show that performed vesicles derived from cytoplasmic vesicle-generating compartments participate in fast release and replenishment using two-photon imaging of single release sites in the intact cochlea. The results demonstrate how the first auditory response can encode with indefatigable precision without having to rely on the slow, local endocytic vesicle cycle.

Care and treatment, Hearing disorders

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Integrated molecular and network biology to decode endocytosis

Article Abstract:

The authors show that a molecular endocytosis, a process used by eukaryotic cells to pack nutrients and other molecules into vesicles from internalization, can refine the network approach and allow derivation of general biological principles.

Physiological aspects, Eukaryotes, Clathrin

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Shiga toxin induces tubular membrane invaginations for its uptake into cells

Article Abstract:

A study about Gb3 (glycolipid)-binding B-subunit of bacterial Shiga toxin that induces narrow tubular membrane invaginations in human and mouse cells and model membranes is reported.

Bacterial toxins, Glycolipids, Cell membranes

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