Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

Article Abstract:

Many dispersed germline V segments must undergo recombination following D-J segment joining to generate the full diversity of antibody heavy-chain genes. The process is reported to be controlled by the alpha-chain of the receptor for interleukin-7, a cytokine stimulating B-cell lymphopoiesis. Ligands of the interleukin-7 receptor provide an extrinsic signal targeting the V-segment recombination in the heavy-chain locus by changing DNA substrate accessibility.

Interleukins

---

Identification and expansion of human colon-cancer-initiating cells

Article Abstract:

The tumorigenic potential of colon [CD133.sup.+] cell is evaluated by comparing the ability of tumor-derived [CD133.sup.+] and [CD133.sup.-] cells to engraft and give rise to subcutaneous tumors in severe combined immunodeficient (SCID) mice. The analysis has suggested that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic [CD133.sup.+] cells.

Italy, Analysis, Diagnosis, Flow cytometry, Colon cancer, Cell separation

---

Aborting the birth of cancer

Article Abstract:

The findings of a study shows that oncogene-driven cell-division cycles trigger DNA damage associated with DNA replication, and this DNA damage raises a barrier to the sustained proliferation of the caner cells. It suggests that for the progression toward full-blown cancer requires the wayward cell to inactivate the mechanisms that monitor damage during DNA replication.

DNA damage, DNA replication

Similar abstracts:

• Abstracts: Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
• Abstracts: Wnt-mediated axon guidance via the Drosophila derailed receptor
• Abstracts: Modelling the recent common ancestry of all living humans. Tracking the first Americans. Craniometric evidence for Palaeamerican survival in Baja California
• Abstracts: Methane and microbes. Warming the world. Release of methane from a volcanic basin as a mechanism for initial Eocene global warming
• Abstracts: Importance of observer experience in finding desert tortoises. Problems with sampling desert tortoises: A simulation analysis based on field data

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.