Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

Article Abstract:

Almost half of the homozygous mice embryos lacking coagulation factor V die on the ninth or tenth embryonic day due to an abnormality in the yolk-sac vasculature. The other 50% of the homozygous mice die within two hours of birth due to massive haemorrhage. Coagulation factor V is important for the stimulation of prothrombin to thrombin, and the study reveals the vital homeostatic function of thrombin besides fibrin clot formation. The genetic deficiency of coagulation factor V causes the congenital bleeding disorder called parahaemophilia.

Observations, Blood coagulation factors, Embryology, Animal embryology, Mice as laboratory animals, House mouse

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Early peak in Antarctic oscillation index

Article Abstract:

The principal extratropical atmospheric circulation mode in the Southern Hemisphere, the Antarctic oscillation, shows a trend towards a positive index in austral summer, which is linked to stratospheric ozone depletion and to increased atmospheric greenhouse-gas concentrations. This positive Antarctic oscillation index, together with the later negative trend after 1960, indicate that natural forcing factors must strongly influence the state of the Antarctic oscillation.

Science & research, Antarctica, Research, Environmental aspects, Greenhouse gases, Ozone layer depletion

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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

Article Abstract:

Results show that the nuclear-encoded mitochondrial serine protese Omi is reduced in the motor neuron degeneration 2, mnd2, mutant mice. Data indicate that deletion of the PDZ domain partially restores protease activity to the inactive recombinant Omni protein. Furthermore, loss of Omi protease activity enhances the susceptibility of mitochondria to permeability disorders.

Analysis, Proteases, Motor neurons, Mitochondria, Structure-activity relationships (Biochemistry), Animal mutation

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