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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Article Abstract:

A JmiC-domain-containing protein implicated in X-linked mental retardation and epilepsy, JARIDIC/SMCX, contains H3K4 tri-demethylase activity and functions as a transcription repressor. The loss of SMCX activity has impaired the RE-1 silencing transcription factor (REST)-mediated neuronal gene regulation, thus contributing to SMCX-associated X-linked mental retardation.

Author: Rao, Anjana, Jing Li, Tahiliani, Mamta, Pinchao Mei, Rui Fang, Leonar, Thiago, Rutenberg, Michael, Shimizu, Fumiko, Yujiang Shi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Protein research

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Article Abstract:

RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of sequence-specific mRNA degradation, triggered by small double-stranded RNAs. The long-term effect of sustained high-level short hairpin RNA (shRNA) expression in livers of adult mice is systematically investigated.

Author: Storm, Theresa A., Kay, Mark A., Pandey, Kusum, Grimm, Dirk, Streetz, Konrad L., Jopling, Catherine L., Davis, Corrine R., Marion, Patricia, Salazar, Felix
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Article Abstract:

RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of sequence-specific mRNA degradation, triggered by small double-stranded RNAs. The long-term effect of sustained high-level short hairpin RNA (shRNA) expression in livers of adult mice is systematically investigated.

Author: Storm, Theresa A., Kay, Mark A., Pandey, Kusum, Grimm, Dirk, Streetz, Konrad L., Jopling, Catherine L., Davis, Corrine R., Marion, Patricia, Salazar, Felix
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
California, Analysis, Physiological aspects, RNA, Liver cells, Hepatocytes, Genetically modified mice, Properties

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Subjects list: Research, Genetic transcription, Transcription (Genetics), Gene silencing, RNA interference
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