Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

Article Abstract:

It has been established that activated human polymerphonuclear neutrophils convert nitrite into NO2Cl and .NO2 through myeloperoxidase-dependent pathways. Nitrite may play a role in phagocyte-mediated oxidative reactions at sites of inflammation and infection. Nitration of tyrosine, and presumably chlorination, acts as a 'footprint' of reactive nitrogen species, and could have a negative effect on cellular function and viability, with this specific function being known to change protein structure and function in vitro.

Research, Physiological aspects, Nitrites, Tyrosine metabolism, Nitration

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PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

Article Abstract:

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear receptor and is an early and pivotal event in the differentiation of adipocytes. PPAR-gamma agonists are shown to suppress monocyte elaboration of inflammatory cytokines, at similar concentrations to those proved to be effective in the promotion of adipogenesis.

Observations, Cytokines, Peroxisomes

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