Genes from zebrafish screens

Article Abstract:

More than 1000 mutations have been obtained in the genetic screens of the zebrafish, Danio rerio. A short breeding cycle, rapid development, and external fertilization and immediate dispersal of eggs, make the zebrafish suitable for genetic studies. The genetic screens expose mutations with zygotic effects, leading to developmental defects. The screens fail to identify various possible mutations that may have been undisclosed or abandoned prematurely. It fails to reveal defects expected from a key gene mutation. A detailed genetic map is available for identifying cloned genes.

Usage, Reports, Gene mutations, Gene mutation, Genetic screening, Genetic testing, Danio

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Mice with half a mind

Article Abstract:

Retinoic acid is implicated in the abnormal development of the brain in vertebrates. A short burst of retinoic acid to vertebrate gastrulae respecifies rhombomeres two and three of the hindbrain region, transforming them to four and five. This respecifies anterior brain regions into more posterior hindbrain. This alteration takes place through the Hox genes, suggesting that these genes are important for the form of the head, in addition to the central nervous system.

Abnormalities, Genetic aspects, Tretinoin, Fetal brain

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Zebrafish pax(b) is involved in the formation of the midbrain-hindbrain boundary

Article Abstract:

A paired box-containing (Pax) gene of zebrafish helps to induce the separation of hindbrain from midbrain during embryological development. The introduction into fertilized zebrafish eggs of an antibody known to attack the activation site of the Pax-dependent protein triggered the abnormal growth of the midbrain-hindbrain. This indicates that the normal function of the Pax gene is to ensure that the hindbrain and midbrain develop properly.

Growth, Mesencephalon

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