Dax1 antagonizes Sry action in mammalian sex determination

Article Abstract:

Mammalian sex-determination is dependent on Sry, a Y-chromosome gene that leads to testes being developed instead of ovaries. Dax1 is a gene that encodes one of the superfamily of nuclear hormone receptors. This gene could be involved in human sex-reversal syndrome, where XY individals become females. XY mice show a delay in the development of the testes if they have additional copies of Dax1. Complete sex reversal can be seen if the transgene is tested against Sry's weak alleles. Dax1 appears to be the main cause of dosage-responsible sex-reversal, and could be the sole cause.

Genetically modified mice, Sex determination, Genetic, Sex determination (Genetics), Genetic code

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Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials

Article Abstract:

Human SRY genes were used to locate and clone homologous genes from the Y chromosome of two marsupial species, Sminthopsis macroura and Macropus eugenii. The SRY gene in both eutherian (placental) and metatherian (marsupial) mammals regulates the testis-determining factor that in turn governs the development of testes and hence of males. The similarity of placental and marsupial SRY genes indicates that the genes evolved quickly. The SRY and Ube1y homologues are the first marsupial Y chromosome genes to be discovered.

Genetic aspects, Evolution (Biology), Homology (Biology), Mammals, Marsupialia, Marsupials, Testis-determining factor

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