Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival
Article Abstract:
Evidence for gigaxonin binding to the light chain (LC) of microtubule-associated protein 1B (MAP1B) is presented and the enhanced degradation of MAP1B-LC by overexpression of gigaxonin is verified. It is concluded that gigaxonin is an ubiquitin scaffolding protein that controls MAP1B-LC degradation and provides insight into the molecular mechanisms characterizing human neurogenerative disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Relays at the membrane
Article Abstract:
The Wnt signaling pathway is a major route, which allows a cell to receive messages from its environment and transfer this signal from the membrane through the cytoplasm and into the nucleus. A gap in the sequence of signaling proteins of Wnt pathway is now filled.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Barbed ends rule
Article Abstract:
Cells use probes of various structures as they interact with their environment. Broad, flat protrusions or long, thin protrusions, they seem to be regulated by proteins at the growing barbed ends of actin filaments.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Spatial representation of shelter locations in meerkats, Suricata suricatta. Frequency of social play does not affect dispersal partnerships in wild meerkats
- Abstracts: Demonstration of quantum teleportation network for continuous variables. Experimental demonstration of five-photon entanglement and open-destination teleportation
- Abstracts: Natural selection on protein-coding genes in the human genome. Evolutionary changes in cis and trans gene regulation
- Abstracts: Doping control for nanotubes. Doping semiconductor nanocrystals. Surface transfer doping of diamond
- Abstracts: Single-exciton optical gain in semiconductor nanocrystals. Hear the noise. Energy-transfer pumping of semiconductor nanocrystals using an epitaxial quantum well