Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development

Article Abstract:

A demonstration that the cooperative activity of Gli3 and Plzf establishes the correct temporal and spatial distribution of chondrocyte progenitors in the proximal limb-bud independently of known P-D patterning makers and overall limb-bud size is presented. The results suggest that the development of proximal and distal skeletal elements is distinctly regulated early during limb-bud formation.

Extremities (Anatomy), Cartilage cells

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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

Article Abstract:

Aberrant transcriptional repression through chromatin remodeling and histone deacetylation is postulated to represent a driving force underlying tumorigenesis because histone deacetylase inhibitors are found to be effective in cancer treatment. The transcriptional repressor Pokemon is identified as a critical factor in oncogenesis.

Histones, Chromatin, Oncogenes

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Cytoplasmic PML function in TGF-beta signaling

Article Abstract:

Cytoplasmic PML (promyelocytic leuk emia) is an essential modulator of transforming growth factor (TGF-beta) signalling. TGF-beta is a pluripotent cytokine that controls key tumour suppressive functions(super 1-3) but cancer cells are often unresponsive to it.

Transforming growth factors, Tumor suppressor genes, Cytokines, Tumour suppressor genes

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