Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons

Article Abstract:

Chemical signalling between neurons is required for rapid information transfer within the brain. Synaptically released glutamate also acts on metabotropic receptors to excite neurons. A unique inhibitory postsynaptic potential (IPSP), mediated by metabotropic glutamate receptor activation, is reported. Calcium from caffeine/ryanodine-sensitive stores was mobilized by activation of metabotropic glutamate receptors (mGluR1), and apamin-sensitive potassium conductance was increased.

Glutamate, Neurotransmitters

---

Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

Article Abstract:

A subtype-specific antibody localizes the D4 subtype dopamine-receptor in GABAergic neurons in the cerebral cortex, hippocampus, thalamic reticular nucleus, substantia nigra and globus pallidus. A subset of cortical pyramidal cells also contains the receptors. The D4-controlled GABA modulation helps in targeting clozapine which is effective in the treatment of schizophrenia. Direct and indirect effects on pyramidal cell firing affect the action of clozapine

Health aspects, Observations, Neurons, Clozapine

---

D2 dopamine receptors and personality traits

Article Abstract:

The density of D2 dopamine receptors in the brain is correlated with a detached personality, which is characterized by lack of closeness and warmth in personal relations. However, it remains to be known whether individual variability in D2-dopamine-receptor density is genetically determined or subject to environmental factors. Neuroreceptor density can be a useful biochemical measure for relating genetics to human personality traits.

Genetic aspects, Neural receptors, Personality, Personality (Psychology)

Similar abstracts:

• Abstracts: Redistribution of synaptic efficacy between neocortical pyramidal neurons. Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids
• Abstracts: Metabolic rate, social status and life-history strategies in Atlantic salmon. Metabolic consequence of agonistic behavior: Crab fights in declining oxygen tensions
• Abstracts: Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction. Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses
• Abstracts: Nestmate discrimination and competition in incipient colonies of fire ants. Entrainment of the circadian rhythm of locomotor activity in wood ants by temperature
• Abstracts: Reproductive success and symmetry in zebra finches. Parental investment, reproductive success and polygyny in the lapwing, Vanellus vanellus

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.