Redistribution of synaptic efficacy between neocortical pyramidal neurons

Article Abstract:

Redistribution of synaptic efficacy between neocortical pyramidal neurons may serve as a mechanism to change the dynamics of synaptic transmission and thus to change content rather than the gain of signals. The physiological implications of redistribution of efficacy are determined by frequency-dependent potentiation. Low-frequency synaptic input increases the synaptic response induced by pairing action-potential activity in pre- and postsynaptic neurons. Increase in synaptic response does not occur due to an increase in the efficacy.

Observations, Neuroplasticity

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Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids

Article Abstract:

Studies done to show that low-threshold-spiking (LTS) cells possess a different form of self-inhibition are presented. LTS interneurons undergo a prominent hyperpolarization mediated by an increased K+-channel conductance and this self-inhibition of neocortical interneurons that lasts for many minutes indicates that it is mediated by the autocrine release of endogenous cannabinoids.

Cannabinoids

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An intrusive chaperone

Article Abstract:

The potential contribution of Stargazin to AMPAR function is explored once the receptor reaches the synaptic membrane. The results suggested that increase in the density of AMPARs at the cell surface could not entirely account for increase in the cell's functional responses to glutamate in the presence of Stargazin.

United States, Receptor antibodies

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