Greasing the Golgi budding machine
Article Abstract:
It is possible that diacylglycerol plays a key role in the process by which transport vesicles form by budding of the membrane on one face of the polarized Golgi complex. Recent research has identified seven genes which bypass the requirement for Sec14p when mutated, and has found that phosphatidylcholine-bound form of phosphatidylinositol transfer protein inhibits phosphatidylcholine synthesis by controlling a rate-limiting enzyme in the pathway. This research may shortly prove influential in providing answers to unresolved questions relating to Golgi budding.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
Article Abstract:
A Drosophila homologue of synaptotagmin IV has been identified, enriched on synaptic vesicles and containing an evolutionarily conserved substitution of aspartate to serine that prevents it binding membranes in response to influx of Ca(super2+). It is suggested that when the expression of synaptotagmins is modulated the resulting heteromultimers can regulate the efficiency of excitation-secretion coupling in vivo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Different domains of synaptotagmin control the choice between kiss-and-run and full fusion
Article Abstract:
Results demonstrate that synaptotagmin regulates the choice of exocytosis mechanisms between full fusion and kiss-and-run, in which vesicles release their contents either through merging or making transient contact with the plasma membrane, respectively. Data indicate that regulation of exocytosis is facilitated by the binding of calcium to the C(sub)2A and C(sub)2B domains of synaptotagmin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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