Heparan sulphate proteoglycans fine-tune mammalian physiology
Article Abstract:
Studies based on model organisms and human diseases that demonstrate the role of Heparan sulphate proteoglycans (HSPGs) in adult physiology with particular emphasis on genetic mouse models and pathophysiological states in humans are reviewed. Results reveal that the electrostatic interaction of the heparan sulphate chains with protein ligands affects metabolism, transport, information transfer, support and regulation in all organ systems.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
Article Abstract:
The Drosophila wingless gene (wg) encodes a protein of the Wnt family, and heparan sulphate proteoglycans are thought to be important for Wg function. The product of division abnormally delayed (dally) has been identified as a heparan sulphate proteoglycan molecule, involved in Wg signalling, and possibly acting as a co-receptor for Wg, together with Drosophila Frizzled 2.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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