Electrical conduction through DNA molecules

Article Abstract:

Experiments involving DNA conductivity use large numbers of DNA strands doped with intercalated donor and acceptor molecules, with conductivity assessed from electron transfer rates, but results remain contradictory. Direct measurements of electrical current as a function of the potential across a few DNA molecules linked to single ropes have been reported. Resistivity values are similar to those of conducting polymers, suggesting that DNA transports electrical current as effectively as a good semiconductor.

Electrical conductivity

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Surface-promoted replication and exponential amplification of DNA analogues

Article Abstract:

The chemical replication of duplex DNA consisting of palindromic homopyrimidine and homopurine strands has been achieved by Li and Nicolaou. An iterative, stepwise method for chemical replication, allowing an exponential increase in oligonucleotide analogue concentrations, is described. It uses the surface-promoted replication and exponential amplification of DNA analogues (SPREAD), which combines the benefits of solid-phase chemistry with chemical replication.

Gene amplification

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