Histone H3 serine 10 phosphorylation by aurora B causes HP1 dissociation from heterochromatin

Article Abstract:

Antibodies against mitotic chromosomal antigens that are associated with human autoimmune diseases specifically recognize heterochromatin protein (H3) molecules that are modified by both tri-methylation of lysine 9 and phosphorylation of serine 10 are presented. H1 dissociates from chromosomes during mitosis, but if phosphorylation of H3 serine 10 is inhibited, HP1 remains chromosome-bound throughout mitosis.

Analysis, Autoimmune diseases, Phosphorylation, Methylation

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The checkpoint brake relieved

Article Abstract:

An innovative model that explains how the activity of the spindle-assembly checkpoint might be maintained, and eventually relieved, when the cell is ready to separate its chromosomes is presented. Researchers have suggested that the anaphase-promoting complex/cyclosome (APC/C) itself might be the molecule that liberates Cdc20 from inhibition by the checkpoint proteins Mad2 and BubR1.

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Myosins meet microtubules

Article Abstract:

The creation and operation of the spindle, which is the central part of the machinery of cell division, is examined. The studies suggest that myosins may interact directly with microtubules and it is also observed that myosins is involved in both spindle assembly and the subsequent positioning of the nuclei during meiosis.

Myosin

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