How far can sequences diverge?

Article Abstract:

The results of two experiments in protein engineering are important for understanding how the conformational requirements of function limit the extent to which proteins can change their sequences during evolution. The findings suggest that protein structures often have the ability to adapt to changes in the shape of buried residues and that various combinations of hydrophobic residues in the core can maintain their structural integrity. The extent to which sequences diverge is inversely linked to the extent of their functional requirements.

Protein engineering, Amino acid sequence, Amino acid sequencing

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Large-scale analysis of the yeast genome by transposon tagging and gene disruption

Article Abstract:

The largest collection of defined yeast mutants ever generated is presented within a single genetic background. More than 11,000 strains were used to determine disruption phenotypes for almost 8,000 strains using 20 different growth conditions. 300 previously non-annotated open reading frames were also identified.

Genomes, Yeast, Yeast (Food product)

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