Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli

Article Abstract:

Research describing the characteristics of cyclic-nucleotide-gated channels activated by hyperpolarization is presented. Particular attention is given to identification of currents activated by hyperpolarization and to processes of immunohistochemistry.

Cases, Cell research, Cytological research, Immunological research, Immunologic research

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Independent evolution of bitter-taste sensitivity in humans and chimpanzees

Article Abstract:

The study shows that phenylthiocarbamide (PTC) taste sensitivity in chimpanzees is also controlled by two common alleles of TAS2R38, however, neither of these alleles is shared with humans. Instead, a mutation of the initiation codon results in the use of an alternative downstream start codon and production of a truncated receptor variant that fails to respond to PTC in vitro.

United States, Behavior, Genetic aspects, Chimpanzees, Codon, Codons

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A TAS1R receptor-based explanation of sweet 'water-taste'

Article Abstract:

A sweet 'water-taste', which is elicited when sweet-taste inhibitors are rinsed away is studied. It is observed that response of cultured cell expressing the human sweetener receptor directly parallel the psychophysical responses-water rinses remove the inhibitor from the heteromeric sweetener receptor TAS1R2-TAS1R3, which activates cells and results in the perception of strong sweetness from pure water.

Food preparations, not elsewhere classified, Sugar and Confectionery Products, Sugar & Confectionery Products, Sugar and Confectionery Product Manufacturing, Sweeteners, Human cell culture

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